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李美璇 Lee, Mei-Hsuan

特聘副教授 / 陽明臨床醫學研究所

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[ CV ]
  • Email: meihlee@ym.edu.tw
  • Tel: (02)2826-7248
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    EDUCATION AND POSITIONS HELD:

    • Ph.D., Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, 2010
    • Postdoctoral Fellow, Genomics Research Center, Academia Sinica, 2010-2012
    • Assistant Professor, Institute of Clinical Medicine, National Yang-Ming University, 2012-

    HONORS:

    • 17th Professor Kung-Pei Chen Memorial Award (陳拱北預防醫學基金會博士論文獎), 2011
    • 21st Wang Ming-Ning Award, Wang Ming-Ning Memorial Foundation (財團法人王民寧先生紀念基金會博士論文獎), 2011
    • Outstanding Postdoctoral Fellow, Genomics Research Center, Academia Sinica (中央研究院基因體研究中心傑出博士後研究員), 2012
    • Young Investigator Award, Asian Pacific Association for the Study of the Liver (APASL) (亞太肝臟醫學會年輕學者獎), 2012
    • The 27th Professor Sung Juei-Low's Academic Prize for Excellent Research (宋瑞樓教授學術基金會優秀論文獎), 2013
    • The Award for Outstanding Contributions in Science and Technology, Executive Yuan (行政院傑出科技貢獻獎) (co-awardee: Prof. Chien-Jen Chen and Dr. Hwai-I Yang), 2013

    RESEARCH INTERESTS:

      My research interests are focus on cancer epidemiology, molecular and genomic epidemiology. In the past years, the works are focus on chronic hepatitis. Hepatitis B or hepatitis C virus infections are important risk factors for liver cirrhosis and hepatocellular carcinoma. To identify biomarkers with predictability for liver cirrhosis or hepatocellular carcinoma among chronic hepatitis B or hepatitis C patients is essential for early diagnosis and intervention. The biomarkers could be used for development of drug targets as well. In addition to the development of biomarkers, we developed prediction models which incorporate host genetic markers, environmental risk factors, and virus variants to better classify high-risk patients who need intensive care. The works might be helpful for prevention and treatment strategies toward personalized medicine.



      我們的研究工作以癌症流行病學、分子與基因體流行病學為主。過去的研究以慢性肝炎為研究主軸。B型及C型肝炎病毒感染是肝硬化及肝癌發生的重要危險因子,尋找可以預測肝硬化或肝癌發生的生物標記,是疾病早期診斷、早期治療的重要預防策略;並且是發展藥物標靶的方向。我們致力於發展這些生物標記外,也發展統合宿主、環境及病毒特性的疾病預測模式,以期找到高危險族群使其接受進一步的醫療處置。這些工作有助於個人化醫療預防及治療策略的發展。

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